Product Overview
Also known as Elamipretide, SS-31 is a mitochondria-targeted tetrapeptide that selectively associates with cardiolipin in the inner mitochondrial membrane. Cardiolipin helps organize the cristae where electron transport and ATP production occur, making it a high-value target in mitochondrial-function research.
Studies have examined SS-31 in models involving reactive oxygen species, mitochondrial membrane structure, ATP recovery, ischemic stress, cardiac and renal function, skeletal-muscle energetics, and age-related mitochondrial decline. Its appeal is directness: rather than broadly influencing metabolism, it concentrates research attention on the architecture and performance of the mitochondria themselves.
For laboratories investigating mitochondrial dysfunction, oxidative stress, or cellular-energy failure, SS-31 is one of the most purpose-built peptides in the catalog.
Common Research Areas
⦁ Cardiolipin binding
⦁ Mitochondrial cristae stability
⦁ ATP production and recovery
⦁ Reactive oxygen species
⦁ Cardiac, renal, and muscle-energy models
Research References
- Szeto HH, et al. “Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury.” Journal of the American Society of Nephrology. 2011;22(6):1041-1052. DOI: 10.1681/ASN.2010080808.
- Sabbah HN, et al. “Chronic Therapy With Elamipretide (MTP-131), a Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure.” Circulation: Heart Failure. 2016;9(5):e002206. DOI: 10.1161/CIRCHEARTFAILURE.115.002206.
