Product Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide supplied by Arche Research as a lyophilized material for lawful laboratory, analytical, and non-clinical research.
Research Context
Epithalon (Ala-Glu-Asp-Gly, also designated AEDG) is a four-amino-acid synthetic tetrapeptide developed at the St. Petersburg Institute of Bioregulation and Gerontology based on the amino acid composition of Epithalamin, a polypeptide complex extracted from bovine pineal gland tissue. The peptide was designed as a short-peptide mimetic of the parent extract and was first detected as a natural component of the pineal gland polypeptide complex in 2017. While originally investigated as a pineal gland bioregulator with effects on melatonin secretion and neuroendocrine function, subsequent research has examined Epithalon for effects on telomerase activation and telomere elongation in somatic cells, epigenetic regulation of gene expression via histone interaction, antioxidant defense enzyme activity, circadian rhythm normalization, and the relationship between telomere maintenance and replicative senescence.
Research References
- Khavinson VKh, Bondarev IE, Butyugov AA. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.” Bulletin of Experimental Biology and Medicine. 2003;135(6):590–592. DOI: 10.1023/A:1025493705728.
- Anisimov VN, Khavinson VKh, et al. “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.” Biogerontology. 2003;4(4):193–202.
- Khavinson V, Diomede F, Mironova E, et al. “AEDG peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism.” Molecules. 2020;25(3):609. DOI: 10.3390/molecules25030609.
- Al-dulaimi S, Thomas R, Matta S, et al. “Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.” Biogerontology. 2025;26:178. DOI: 10.1007/s10522-025-10315-x.
