Product Overview
MOTS-c is encoded within mitochondrial DNA and functions as a mitochondrial-derived signaling peptide. Instead of acting only inside the mitochondria, it has been studied as a messenger that helps coordinate cellular energy status with broader metabolic responses.
Its best-known research connection is AMPK activation – a central energy-sensing pathway involved in glucose uptake, insulin sensitivity, fuel selection, and adaptation to metabolic stress. Studies have also explored skeletal-muscle function, exercise response, age-related physical decline, and the relationship between mitochondrial communication and metabolic homeostasis.
For researchers working at the intersection of mitochondrial biology, performance adaptation, and glucose regulation, MOTS-c offers one of the most direct peptide models available.
Common Research Areas
⦁ AMPK and cellular energy sensing
⦁ Glucose metabolism and insulin signaling
⦁ Mitochondrial-to-nuclear communication
⦁ Skeletal-muscle adaptation
⦁ Exercise and age-related metabolic research
Research References
- Lee C, et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism. 2015;21(3):443-454. DOI: 10.1016/j.cmet.2015.02.009.
- Reynolds JC, et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications. 2021;12(1):5564. DOI: 10.1038/s41467-021-25715-2.
