Product Overview
MOTS-c is a synthetic research compound supplied by Arche Research as a lyophilized material for lawful laboratory, analytical, and non-clinical research. Multiple nominal quantities are available through the strength selector on this page.
Research Context
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) has been examined in published preclinical and clinical research involving its activity as a mitochondrial-derived peptide (MDP) that regulates metabolic homeostasis. Investigations have primarily focused on its ability to activate AMPK, improve insulin sensitivity, modulate glucose metabolism, and influence skeletal muscle adaptation and exercise capacity in clinical and preclinical trial settings. The references provided below are included to identify relevant scientific literature and do not constitute product-use, medical, or administration guidance.
Research References
- Lee C, et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism. 2015;21(3):443-454. DOI: 10.1016/j.cmet.2015.02.009.
- Reynolds JC, et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications. 2021;12(1):5564. DOI: 10.1038/s41467-021-25715-2.
